The work aims to take dairy product package as research object to establish a set of methods that can scientifically evaluate the safety risk of food contact materials and comprehensively evaluate the food safety risks caused by food contact materials in the process of contacting food. Non-targeted high-throughput screening detection technology was used to screen the heavy metals and organic compounds in food simulants. Hazard assessment was carried out according to authoritative databases and material toxicology data. Exposure assessment was conducted with reference to the dietary exposure calculation methods of the European Union and the United States and the risk coefficient was calculated in combination with the assessment results. Finally, the safety risk of food contact materials was characterized. Dairy product packages made of different materials such as plastic, metal, coating and composite materials on the market were selected for detection. Elements such as copper, chromium, manganese and tin, intentional additives such as monomers, solvents, antioxidants, photoinitiators, smoothing agents and plasticizers, and unintended additives such as antioxidant degradation products and oligomers were found through detection. The dietary exposure and health guidance values of the detected substances were characterized by exposure assessment and hazard assessment methods. The risk coefficient of safety risk assessment was 0.007%-9.4%, resulting in low safety risk. The safety assessment method of food contact materials established is an effective method to evaluate the safety risk of food contact materials. This method has certain universality, and can be used by enterprises, industries and government departments to identify the safety risk of food contact materials, and provide a scientific basis for reducing and eliminating the safety risk.