The work aims to provide reasonable suggestions for the research and application of curcumin-mediated photodynamic technology in fresh-cut fruits and vegetables by introducing its research progress. The action mechanism of curcumin-mediated photodynamic technology was discussed, and the literature about its effects on the quality of fresh-cut fruits and vegetables in China and abroad was reviewed. Then, the fresh-keeping and bacteriostatic effects of curcumin-mediated photodynamic technology for fresh-cut fruits and vegetables were analyzed, and its affecting factors and safety were introduced. Finally, the application prospect of curcumin-mediated photodynamic technology in fresh-cut fruits and vegetables was studied. Curcumin-mediated photodynamic technology could effectively inhibit the growth of microorganisms in fresh-cut fruits and vegetables and maintain the quality of fresh-cut fruits and vegetables. Curcumin-mediated photodynamic technology is an effective sterilization method, which has great application potential and needs to be developed and utilized reasonably.