The work aims to study the effects of different packaging materials on the change of cigarette moisture content. The grammage, thickness and water vapor transmittance of different types of packaging paper were determined and the micromorphology of the paper was analyzed by scanning electron microscope. Then, the cigarettes packed with ceramic-coated white cardboard, ceramic-coated medium paper and ordinary packaging were unpacked and placed in natural environment, dry environment with normal temperature and humid environment with normal temperature. The changes of moisture content of cigarettes were measured, and the content of water-soluble sugar and key chemical components in cigarettes were analyzed. Finally, the cigarettes packed with three kinds of materials were assessed by sensory evaluation. There was no obvious difference in the grammage and thickness of three kinds of packaging paper. Under dry environment with normal temperature and humid environment with normal temperature, the medium packaging box with ceramic coating showed better moisture-proofing and moisture-preserving effect and the best sensory quality. The packaging material has a direct effect on the moisture content and comprehensive sensory scores of cigarette. The ceramic-coated medium paper in this study has better moisture-proofing and moisture-preserving effect, which has promotion value in the field of tobacco package.