The work aims to conduct preservative treatment on wood to meet the use requirements and epidemic prevention requirements of wood packaging materials. However, the traditional preservative treatment is easy to cause pollution to the environment and goods. Bio-based preservative technology can solve the above problems. The current situation of the use of wood packaging materials was introduced. The research progress of bio-based preservative at home and abroad was expounded. The problems existing in the use of wood packaging materials were analyzed and discussed. Bio-based preservative technology was a green and efficient wood preservative technology, which had achieved certain research results. The bio-based preservative technology can meet various needs of wood packaging materials in transportation and storage, and has the advantages of environmental protection and non-toxic property, so it has a very broad development and application prospects.