The work aims to design a new type of packaging box in view of the long processing cycle, high development cost and inconsistent dimensions and difficult management and transportation caused by many customized products of the traditional aluminum distribution packaging box for small-sized aerospace precision instrument. A non-metallic precision instrument distribution packaging box suitable for commercial transportation was designed by selecting new box materials, designing the box structure, altering the form of processing technology, changing the way of product installation and internal protective damping materials. Through the simulation test on harsh commercial transportation, the small-sized aerospace precision instrument distribution packaging box could realize multiple packing in one box, had the functions of vibration isolation, moisture protection, etc. and saved the cost, shortened the development cycle, and was easy to manage and transport. The packaging box can meet the transportation and storage of small-sized aerospace precision instrument, and its structure and test results can provide reference for the subsequent development of this kind of packaging box.