The work aims to improve the detection accuracy of aluminum foil sealability of daily chemical bottle. A method for detecting aluminum foil sealability of daily chemical bottle was proposed. Pressure was applied to daily chemical bottle sealed with aluminum foil to make it deform to a certain extent. Based on the reaction force generated by the daily chemical bottle during the process of applying pressure, an air leak mathematical model was established to judge the aluminum foil sealability of daily chemical bottle. An experimental platform for detecting aluminum foil sealability of daily chemical bottle was designed, and the aluminum foil sealability of daily chemical bottle was detected under different extrusion strokes and extrusion speed. After the data obtained from the experiment were brought into the air leak mathematical model, the maximum error between the value of the leakage area obtained and the actual value was 4.5%. The method for detecting aluminum foil sealability of daily chemical bottle is simple and accurate, which provides a basis for detecting aluminum foil sealability of daily chemical bottle in the actual production.