Vaccines are subject to temperature, radiation and other factors during production and transportation, which will affect their titers. The conjugated diacetylene Vaccine Vial Monitor(VVM) can closely link these influencing factors with vaccine stability, so as to provide theoretical references for its application in VVM. This paper briefly expounds the solid-phase polymerization mechanism of conjugated diacetylene, and the structural requirements of conjugated diacetylene monomers that can undergo solid-phase polymerization. Besides the factors that can cause the change of polymerization rate of conjugated diacetylene monomer are summarized. Then, the research status and application of conjugated diacetylene monomers as VVM are summarized. Finally, the existing problems and future development directions of conjugated diacetylene monomer based on VVM in our country are analyzed and prospected. By selecting conjugated diacetylene monomers with obvious discoloration during polymerization, and adding different kinds of free radical initiators, the polymerization rate of conjugated diacetylene monomers can be adjusted to match the shelf life and transportation requirements of different products. This type of label better indicates the effectiveness of vaccines and can also greatly reduce the cost of our country's vaccine exports.