The work aims to propose the general construction conception of modern military logistics information system and provide theoretical support and reference for the actual construction of modern military logistics information system. From the general structure of information system, the main construction contents of modern military logistics information system were systematically expounded. The construction conception of “one data center, three communication networks, four subsystems, four databases and four situation maps” was put forward. The construction of modern military logistics information system is a complex system engineering and all aspects of construction need to be coordinated and integrated.