The work aims to predict and take improvement and elimination measures in time to solve the problems in type, die cutting and indentation of framed packaging box for liquor to improve the efficiency, stabilize the quality, reduce the cost and improve the effectiveness. The problems in paper grain direction, moisture content, pressure, die cutting and indentation were analyzed and eliminated to improve production quality. In terms of box type, it was proposed to determine the paper grain direction and select the appropriate moisture content improvement method, and eliminate effect of the poor paper quality on the box quality through the selection of the appropriate die cutting knife, the correct selection of indentation line and the bottom mold, and ensure that the indentation meets the quality requirements through, reasonable selection of indentation line, bottom mold, correct and reasonable adjustment of the indentation pressure. Adhering to the box type, die cutting and indentation and other issues as the orientation, focusing on the whole process of processing, strengthening the management of production links, and emphasizing details for benefit have certain reference significance for the packaging and printing industry.