The work aims to study the deformation mechanism and compression resistance of multi-layer UV-shaped corrugated board under axial crushing to promote the design of multi-layer corrugated case and cushion packaging. The theoretical analysis was combined with experimental study. The theoretical modeling and quasi-static experimental study of the platform stress after axial crushing of multilayer UV-shaped corrugated board were carried out. Based on the production process of UV-shaped corrugated board, a physical surface bonding was assumed to represent the interaction between the core liner and the outside liner; then, a new folding element and three folding modes of the corrugated core were proposed based on experimental phenomena. Moreover, a platform stress model of five-layer and seven-layer corrugated boards was proposed. It was found that the platform stress predicted by the developed model compared well with the experimental results. It can be concluded that the proposed model is effective and helpful for stiffness design and parameters selection of corrugated structures to meet different strength requirements.