The work aims to explore the application of intelligent drug packaging materials in the multi-sensory dimension, so that drug packaging materials can play a higher application value on the basis of intelligence, better meet people’s sensory needs, and promote the development of the drug packaging industry. Firstly, intelligent drug packaging materials and multi-sensory packaging were summarized. Secondly, the vision, hearing, smell, taste, touch and multi-sensory combination applications of intelligent drug packaging materials were emphatically expounded. Finally, the development trend was analyzed to mobilize different senses according to group characteristics, enhance research on applications in smell and taste, and combine intelligent drug packaging materials, structures and technologies. As for intelligent drug packaging materials, the psychological and sensory needs of consumers are less explored. The integration of multi-sensory combination and intelligent drug packaging materials is a further development of intelligent drug packaging. Multi-sensory combination builds a bridge between consumers and products, meets consumers’ physical and psychological needs, and provides a reference for the development of intelligent drug packaging materials.