The work aims to provide investigators with comprehensive insights and recent advances related to OSCs manufacturing technology, analyze existing technical bottlenecks and unsolved scale efficiency losses to obtain scalable and printable large-area photovoltaic modules. This review introduced the selection of functional layer materials, the current status of printing process research and large-scale efficiency loss, and focused on the technical challenges in printing and preparation of flexible and high-efficiency large-area organic photovoltaic devices. This will promote the integrated application of printable organic semiconductor materials in next-generation clean energy, and attract widespread attention in application to wearable electronics, building-integrated photovoltaics, the Internet of Things, etc.