The work aims to study the value and significance of time-temperature indicator (TTI) in product packaging and cold chain logistics and implement strict monitoring on the cold chain logistics process to safeguard public health and food hygiene safety. The types and principles of several common TTI were briefly described and the research status of TTI was summarized. At the same time, the development trend of TTI technology was generalized and its commercial prospect in China was expected. After decades of development, TTI technology was relatively mature and played an important role in cold chain transportation, logistics management and other fields. TTI technology has a broad application and development prospect. When combined with technologies in the fields of intelligent packaging and logistics management, TTI technology will speed up its commercialization process in China.