The work aims to design a reliable and suitable carton folding of multiple specifications to solve the problem that the folding mechanism of the carton packaging machine on the existing carton automatic packaging production line is unreliable and cannot fold the carton of multiple specifications, so as to improve the quality and efficiency of carton packaging. By analyzing and researching the folding function, carton status and the packaging machine as a whole, two carton folding mechanisms were designed; the dynamic static analysis method of the mechanism was used. Matlab was used to solve the kinematics and dynamics equations; SolidWorks software was used to carry out structural design and three-dimensional modeling of the two folding mechanisms. The two folding mechanisms designed were assembled on the packaging machine for on-site testing. The kinematic analysis results showed that the final angular displacements of the two folding mechanisms driving the carton page rotation can accurately make the carton pages complete the folding work; the dynamic analysis results showed that the driving torque and driving force required by the two folding mechanisms conformed to the use range of torque and force of power components. Field test results showed that the designed folding mechanism could achieve reliable folding of cartons of various specifications. The carton folding mechanism can reliably complete carton folding of different specifications and realize the automation and flexibility of carton folding, and can improve the packaging efficiency of the carton packaging production line to a certain extent.