The work aims to predict the shelf life of moisture-proof packaging for whole milk powder considering the interaction among environment, packaging and product. The isothermal hygroscopic model was used to characterize the hygroscopic characteristics of whole milk powder. Considering the effect of temperature on the moisture permeability of packaging materials and the hygroscopic characteristics of products, the shelf life prediction model of moisture-proof packaging of whole milk powder based on the effect of temperature and humidity was established combined with sensory evaluation indexes. At (70±1)% relative humidity and (37±1)℃, the accelerated tests were carried out on the whole milk powder packaged by film with different water vapor permeability to verify the validity of the model. GDW (Generalised D'Arcy and Watt) model could effectively characterize the moisture absorption characteristics of whole milk powder. The critical moisture content of whole milk powder during shelf life was 4.85%. Under accelerated test conditions, the predicted shelf life of milk powder packaged by polyethylene film and aluminum-plastic film was 89 days and 249 days respectively, and the prediction model of moisture-proof packaging for whole milk powder had high accuracy (relative deviation was less than 6%). Temperature has a great effect on the hygroscopic characteristics of whole milk powder and the moisture permeability of packaging materials, so the establishment of moisture-proof packaging shelf life prediction model with wider applicability of temperature can provide support for the shelf life research and practical application of powdery dairy products.