The work aims to further improve the bonding property of esterified glutinous rice starch label adhesive and meet the national standard. Maleic anhydride was used to esterify glutinous rice starch on the basis of succinic anhydride. The optimal conditions were determined by single factor and response surface tests, and the structural characteristics, bonding strength, peel strength and water-resistant time were measured. The optimal process conditions of maleic anhydride secondary esterification of glutinous rice starch were as follows:the secondary esterification time was 77 min, the esterification temperature was 45.3℃, and the esterification pH was 9.0. Under these conditions, the bonding strength of glutinous rice starch label adhesive was 250.672 N/m, and the peel strength was 216.935 N/m. Compared with the non-esterified adhesive, the adhesive strength was increased by 55.64% and the peel strength was increased by 122%. Compared with the single esterification, the adhesive strength of the label was increased by 48.77% and the peel strength was increased by 76.73%. And the water resistance of the label adhesive after double esterification was greatly improved. Fourier infrared spectrum analysis showed that ester group characteristic peaks existed in the esterified starch molecule at 1730 cm-1. And scanning electron microscope analysis showed that starch grains disintegrated after secondary esterification. The surface was rough, depression and crack appeared. Thermodynamic properties showed that esterified starch had lower gelatinization temperature. The bonding property and water resistance of glutinous rice starch label adhesive are greatly enhanced after the double esterification of succinic anhydride and maleic anhydride.