The work aims to study the deviation correction control system of traditional pillow packaging machine to solve the deviation in application. Based on the working principle of single chip microcomputer, the deviation correction control circuit of pillow packaging machine was designed, and three pulse frequencies of the deviation correction control circuit were given. According to the control rules of machine vision and the working principle of the deviation correction controller of pillow packaging machine, the deviation correction controller of pillow packaging machine was designed. According to the deviation correction requirements, CCD sensor and frequency modulation and voltage stabilizing circuit were designed. The toolbox related to the domain deviation correction control system was adopted to design the deviation correction control rate parameters of pillow packaging machine. Based on the mathematical form of deviation correction control of pillow packaging machine, the deviation correction control increment of pillow packaging machine was calculated. Combined with the incremental control principle, the deviation correction control program of pillow packaging machine was designed, and the software design of the system was completed. The deviation correction control system of pillow packaging machine based on machine vision could not only improve the deviation correction control accuracy of pillow packaging machine, but also stabilize the system response time within 2 s. The designed deviation correction control system can improve the deviation correction control accuracy, shorten the system response time and improve the performance of the system.