The work aims to design a tension control system of labeling machine based on double fuzzy PID controller, so as to improve the labeling accuracy of drug packaging. The structure and process flow of drug packaging production line were briefly discussed. Aiming at the characteristics of time-variation, nonlinearity and dynamic disturbance in the winding process of label paper tape, a double fuzzy PID tension controller was designed. The parameter tuning of the main fuzzy controller was realized by the sub-fuzzy controller, while the main fuzzy controller could adjust the parameters of the PID controller. The effectiveness of the control system was verified by experiments. From the experimental results, compared with the PID controller, the double fuzzy PID control could reduce the system overshoot by 50% and the system adjustment time by 65%. The labeling position was accurate and the label was attached smoothly. The control system has good anti-interference performance, excellent labeling effect and certain use value.