The purpose of this paper is to provide a feasible scheme for the automatic transformation project of ash packaging production line in a waste incineration plant, and design a fully automatic ash packaging intelligent production line. Based on the actual technological requirements of ash packaging, the overall design of production line and the layout of workstations were introduced. The design and working principle of neckline-opening device and robot special chucking claws were introduced. The formula of theoretical hitching-bag force was derived to guide the design of special chucking claws and ash dispensing barrel. On the basis of the structure design of the production line, virtual commissioning method based on NX MCD and virtual PLC was adopted to further verified whether the structure and layout can achieve all the working procedures of ash packaging without obstacles and simulate the working procedures of the whole packaging production line by combining PLC program. The simulation showed that the production line can realize 11 processes of ash packaging under control of PLC program fully-automatically and without boundaries. All 6 workstations of the production line can achieve unmanned operation. The original semi-automatic packaging production line can be modified by adding neckline opening device and robot and other equipment, which can solve the problems of automatic neckline-opening, taking and hitching for large jumbo bags for the original line.