Because of the transportation environment, bottle state, and the change of the air pressure, leakage will appear at the bottletneck of the packing pressing bottles during travel. This paper mainly introduces the application of TRIZ theory. Firstly, we must confirm the components and its acting objects by defining the technical system. Then we can get the leaking key points and reasons after functional model analysis and causal analysis. Thirdly, we will find corresponding creative theory by a series of tools on technical, physical contradictions and material field analysis. And these tools should be combined with contradiction matrix and spatial isolation.We select the useful inventive principles, getdifferent solving cases, and thenoptimize and verify the cases.We can acquire the innovative design of new anti- leakage packing pressing bottle. The new anti- leakage packing pressing bottle not only improves the satisfaction of consumers, but also reduces the production cost and simplifies the processing process, which has strong practical production significance. The innovative anti- leakage design based on TRIZ theory also simplifies the process, improves the utilization rate of the contents and saves the packing materials.