In order to solve the problem that corrugated boxes are easy to be affected by moisture and lose their original properties, the superhydrophobic and moisture-proof modification was carried out, and the effect of modification on their performance was studied. Stearic acid with low surface energy was combined with nano silica particles which can construct surface roughness, and then polydimethylsiloxane was introduced to enhance the adhesion between the coating and paperboard. The moisture-proof carton was prepared by vacuum adsorption coating, and its wettability and mechanical properties were characterized. The water contact angle of the modified cardboard can reach more than 150° and the water adsorption rate was greatly reduced. On this basis, the edgewise compressive strength was not affected, and the wear resistance was excellent. The preparation process of the superhydrophobic coating described in this paper is simple and the materials are green and environmentally friendly. The obtained carton has good moisture resistance, mechanical properties, and mechanical properties.