With the rapid development of 5G technology, intelligent packaging has attracted many concerns. The work aims to summarize the flexible sensor technology and its application examples in intelligent packaging in recent years so as to provide reference for the research and application of intelligent packaging technology in the future. Through the literature analysis of the research status of flexible sensor technologies such as flexible printing electronic technology, carbon nanotechnology and silicon optoelectronic technology, related applications of flexible sensors in food quality detection, tamper-evident packaging design and e-commerce logistics monitoring were summarized to provide reference and suggestions for further improvement of flexible sensors in intelligent packaging. A large number of studies show that the application of flexible sensors in intelligent packaging is still in its infancy, various technologies are still growing, and it does not have complete commercial feasibility. The flexible sensor broadens the function and application field of intelligent packaging, and can provide good monitoring, recording and guarantee for internal products. It is worthwhile to increase research and development investment and study in-depth.