The work aims to reduce the VOCs gas collection space of printing equipment, improve the efficiency of VOCs gas collection, and save the cost of enterprise waste discharge. Based on the existing four open two-color printing presses in laboratory, a three-dimensional model of the printing press was built with rotary parts such as the printing roller, fixed fittings, connection between the wall and beams, and the blank place on both sides of the wall to increase the wallboard hole as inspiration source. The seal measures before and after shield machine were improved to form a sealed state with wall plates on both sides. The VOCs air collection space was completely limited in the machine. The VOCs air collection space of the machine can be limited to 2 cubic meters from the 18 cubic meters under the cover mode above the original machine, which can reduce the useless air collection volume by more than 85% at least. After deducting the space occupied by the internal parts of the machine, the useless gas collecting space can be further reduced. If the gas collecting technology is used to carry out technical transformation on the printing press and other similar packaging printing equipment, the power of the VOCs processing equipment configured for this purpose can be greatly reduced.