In order to solve the problem of protection failure caused by creep of cushioning material foamed polyethylene, the effects of load and stress holding time on the compressive creep behavior of EPE cushioning material were analyzed based on Burgers model. Based on the results of the compression creep test results of different holding time under different stresses, the compression creep test data of EPE under different stresses were fitted to analyze the changes of creep total, elastic strain, viscoelastic strain and viscous strain during the creep process of EPE under different stresses and stress holding time. The experimental data fit of Burgers four-element mechanical model for compression creep of EPE under different stresses ranged from 0.992 4 to 0.998 9. At the same stress holding time, as the stress increased from 3.3 kPa to 5.3 kPa, the elastic modulus E1, elastic modulus E2, viscosity coefficient η2 and viscosity coefficient η1 all decrease. The total creep and viscous strain increase nonlinearly, while the elastic strain and viscoelastic strain increase linearly. At the same stress, as the stress retention time increases from 20 days to 120 days, the elastic strain remains constant and its proportion to the total creep decreases. The viscoelastic strain increases slightly at first and then remains constant, and its proportion to the total creep decreases while the viscous strain increases and its proportion to the total creep increases. Burgers model can accurately simulate the compressive creep behavior of EPE in unstable creep stage and stable creep stage. The increase of stress leads to the weakening of EPE's ability to resist deformation and the increase of creep. The increase of stress holding time has no effect on the elastic strain, and has no effect on the viscoelastic strain in the stable creep stage, but has a significant effect on the increase of viscous strain.