The work aims to quickly and accurately carry out non-destructive test to the drug aluminum plastic packaging tablet left at the crime scene. The latest differential Raman spectrometer was used to analyze the 51 samples of drug aluminum plastic packaging tablets collected at the crime scene based on chemometrics. A total of 9 effective components were extracted from the collected samples of drug aluminum plastic packaging tablets, with accumulated effective information accounting for 99.54% of the original spectral data. Then, the 51 samples were divided into 4 categories. Through correlation comparison, the classification results were better. The experimental method is simple and reproducible, and the experimental results of non-destructive test are good, which provides the basis for the inspection of material evidence of drug aluminum plastic packaging tablets and can effectively help the development of public security work.