The work aims to propose design criteria and design program for lightweight engineering with frame structure of certain heavy equipment for transportation as the research object to solve the problem of excessive packaging of heavy equipment. Numerical simulation analysis was carried out on the lifting and stacking conditions of the steel frame packaging boxes for transportation with software Ansys. The empirical design plan was improved based on the analysis results. The weight of the optimized steel frame box was reduced by 942 kg, and the weight reduction ratio reached 43%. The static strength safety factor of the lifting condition was 2.14, while the static strength safety factor of stacking condition was 1.94. The safety factor of stability was 4.96 times. The steel frame box of engineering lightweight design meets the safety performance specified by the yield strength failure criterion and the stability failure criterion, which not only improves the use efficiency of materials, but also significantly reduces the packaging cost.