The work aims to study the vibration response characteristics of cushioning packaging system of products with unbalanced mass under different installation modes of spring isolators. The mathematical model of the cushioning packaging system of products with unbalanced mass was established, and the vibration response was compared and analyzed by the fourth-order Runge Kutta method. Through finite element simulation, the vibration response characteristics of unbalanced-mass products with different number and installation positions of lateral springs were simulated, and the feasibility of correction was analyzed. Then, the experimental method was used for verification. When 1 lateral spring was installed at the center of lateral edge and 2 lateral springs were installed at the lateral edge, the correction effect of vibration response of unbalanced-mass product cushioning system was the best. The mass center offset has a great effect on the acceleration of the cushioning system of products with unbalanced mass. When the eccentric distance is large, the spring stiffness in the direction of large eccentric displacement can be appropriately changed for correction and optimization, so as to provide a method and basis for the cushioning packaging design of products with unbalanced mass.