The work aims to develop a special design and analysis system for the whole machine cam linkage mechanism of food packaging equipment based on the secondary development of SW and provide an intuitive evaluation method for the stability and non-interference of the whole machine actuator movement by virtue of SW. According to the movement form of the actuator and the structure form of the cam linkage mechanism, VS was used as the development tool to build the C++ development environment based on SW 3D modeling tool to develop the CAD system of the whole machine cam linkage. The whole machine actuator was taken as the research object. ADAMS and Ansys were adopted to complete simulation analysis of rigid flexible coupling. The influences of the flexibility of the main load-bearing bar and the slender bar on the stability and non-interference of the whole actuator were studied, to verify the rationality of the design of the whole machine cam linkage mechanism. The rigid flexible coupling simulation of the whole machine cam linkage mechanism was completed at high speed. The results met the design requirements of action sequence. The maximum deviation rate of the displacement of the upper punch actuator was 0.08%; and the maximum deviation rate of the speed was 0.05%. The acceleration was basically consistent with the theoretical design, so it had good stability and non-interference. The results of rigid flexible coupling simulation can correctly reflect the stability and non-interference of the whole machine actuator movement process, which verifies the rationality of the system design of the whole machine cam linkage mechanism.