The work aims to investigate the attenuation characteristics of neotame in sweet tipping paper and provide a reference for clarifying the storage period of neotame tipping paper. Six types of cigarette tipping paper with different neotame contents were designed and prepared, and the effect of storage period on attenuation of neotame in cigarette tipping paper was investigated by high performance liquid chromatography-diode array detector (HPLC-DAD) method. The method had good linearity in the mass concentration range of 75~500 μg/mL (r≥0.999), and the average recovery rate was between 92.31% and 103.75% (RSD=0.35%～2.32%, n=5). 1#~3#, 4# and 6#, 5# tipping paper had a plateau period of 20~100 d, 20~160 d, and 80~160 d respectively. Within 0~100 d, the attenuation rate of the tipping paper with neotame of 0.47~0.62 mg/g and 0.82~1.37 mg/g was between 19.15%~33.87% and 11.68%~31.62%, respectively. Within 100~200 d, the attenuation rate of the tipping paper with neotame of 0.47~0.62 mg/g and 0.82~1.37 mg/g was 42.55%~95.74% and 23.36%~65.85%, respectively. This method is suitable for the determination of neotame content in sweet tipping paper for cigarettes. The stable period of neotame in the tipping paper increases with the increase of the addition content. Within 0~100 d, the neotame content in the tipping paper decays slowly and the attenuation rate of the tipping paper with different addition contents is basically the same. Within 100~200 d, the neotame content in the tipping paper decays fast, and the attenuation rate decreases with the increase of the addition content. The storage period of the tipping paper with neotame in the range of 0.47~0.62 mg/g is within 200 days, while the storage period of the tipping paper with neotame in the range of 0.82 ~1.37 mg/g is still uncertain.