The work aims to predict the oxygen permeability of miscibility blended film, and provide a theoretical support for the manufacture and design of high oxygen barrier blended film. In this research,a prediction model of oxygen permeability was proposed according to the application of fractal theory and percolation theory. This model can predict oxygen permeability of miscibility blended films more accurately at a high content (mass fraction) of oxygen barrier polymer. A scanning electron microscopy (SEM) was used to analyze the micro-structure of PET/PEN blended films, determine the dimension of oxygen permeability in PET/PEN blended films. Then the oxygen permeability of PET/PEN blended film was calculated according to the permeability dimension combined with the prediction model proposed in this work. Finally, the validity of the model was verified by experimental data. The results indicated that the oxygen permeation in PET/PEN blended films can be simplified into a 2-D percolation. Both the existing model and the proposed model had a good agreement with the experimental data at low PEN content (volume fraction). However, the proposed model showed a unique curve trend which had a more accurate prediction to experimental data at the high PEN content (volume fraction) in blended films and can describe the barrier effect of high oxygen barrier polymer on oxygen in the blended film system more accurately. The proposed model can be used to predict the oxygen permeability of miscibility blended film.