The work aims to study the migration laws of bisphenol A (BPA) and bisphenol S (BPS) in paper toys by oral exposure and investigate the applicability of BPA and BPS migration. The migration laws of bisphenol compounds were studied by indirect enzyme linked immunosorbent (IC-ELISA) and Fick's second law under the conditions of different temperature (4, 37, 60 ℃), salt concentration (0.001, 0.01, 0.1 mol/L), pH (4, 7, 9) to simulate the migration of BPA and BPS in paper toys. The migration amount was positively correlated with temperature and salt ion concentration, and the dissolution increased in the simulated solution under acidic and alkaline pH conditions. The migration laws of BPA and BPS in paper toys by oral exposure conformed to Fick's second law. Under the normal migration simulation conditions (37 ℃, salt concentration of 0.01 mol/L and pH 7 of saliva simulated solution), the migration coefficient of BPA and BPS was 1.3×10−17 and 6.6×10−18 cm2/s respectively. Based on enzyme immunoassay, the migration model of BPA and BPS in paper toys is constructed and successfully applied to predict the migration behavior of bisphenol compounds in paper toys. According to the migration simulation experiment of bisphenol in paper toys, the diffusion coefficients of bisphenol under different conditions are calculated and the migration model is fitted to predict the migration of BPA and BPS in blind samples. In comparison with the actual migration, the theoretical prediction value is basically consistent with the actual migration amount. The work is of great significance for risk assessment of bisphenol compounds in children's paper toys.