The work aims to analyze and study the migration of copper and zinc of regreen indocalamus leaves in different food stimulants, so as to provide a theoretical basis for the quality and safety control of indocalamus leaves used for food packaging. Six portions of 25 g of indocalamus leaves were taken and placed in six food simulants respectively, and then heated at 100 ℃ for 24 hours. The concentrations of copper and zinc in regreen indocalamus leaves were measured by microwave digestion-Flame Atomic Absorption Spectrometry (AAS) to evaluate the migration in food simulants before and after treatment.Finally, the migration amount was calculated and the migration situation was analyzed. Neither copper nor zinc in regreen indocalamus leaves migrated in alkaline buffer solution (pH 10.14), but both of them migrated in varying degrees in other 5 food simulants. Copper migrated with maximum amount in soybean oil by 4.7 mg/L, and zinc migrated with maximum amount in 4% acetic acid solution by 17.5 mg/L. Neither copper nor zinc in regreen indocalamus leaves migrate in alkaline buffer solution, but both of them migrate in varying degrees in other 5 food simulants. There is a food safety risk in the food wrapped with regreen indocalamus leaves. Based on the study results and the fact that there is no standard for the source and migration limits of green compounds in natural food packaging materials in China, it should be prohibited to use regreen indocalamus leaves as food packaging materials.