In order to realize information recording, information hiding and information anti-counterfeiting, a kind of information reliability codec algorithm is designed to solve the prominent problem of high bit error rate caused by the stain of printed information and the misjudgment of image reading information when the dot matrix image of printed quantum dots is used to realize information recording, information hiding and information anti-counterfeiting. The algorithm adopts the combination mode of two-dimensional Parity Check code, BCH code, interleaved code and frame synchronization. The experimental results show that compared with Hamming code and RS code, the image of printed quantum dots obtained by the combined coding method has higher randomness, more prominent error correction ability, faster information decoding and reading speed and better robustness. This algorithm can well solve the sudden error and random error of printed quantum dot information, and also solve the bottleneck problem of the application and promotion of printed quantum dot image in the field of information anti-counterfeiting, and expand the value-added service function of information.