The paper aims to compare and analyze the migration of AA under conditions of biting and licking exposure by enzyme-linked immunosorbent assay (ELISA) method for derivatization of acrylamide to evaluate the average daily intake of AA and cancer risk of young children (3-36 months) exposed to paper toys. The oral exposure conditions including temperature (4, 37, 60 ℃), salt concentration (0.001, 0.01, 0.1 mol/L) and pH (2, 7, 9) were simulated to study the migration of AA. Based on the migration curve and Fick's second law, the corresponding migration model was fitted and applied to predict the migration of actual samples. According to ELISA, the recovery rate of which was 84.45%- 92.31%, the difference of AA migration based on biting and licking model was analyzed. Migration of acrylamide was positively correlated with the temperature and salt ion concentration of saliva simulant and the change of pH would increase the dissolution of acrylamide. The average daily intake of AA and cancer risk of young children exposed to paper toys were evaluated, which was lower than the risk threshold. Therefore, the migration risk of AA in paper toys is greater under bitting model. When the temperature is 37 ℃, ionic concentration is 0.01 mol/L and pH is 7, the Dpvalue is 2.20 μm2/s, the correlation coefficient R2 of the migration model is 0.90 ~ 0.98, and the correlation coefficientof the linear curve used to predict AA in children's paper toys is 0.97, which indicates that the model can be used to predict the migration of AA in children's paper toys. This work is of great significance to the risk assessment of children's exposure to paper toys.