The work aims to determine the best extraction technology of lycium pigment by comparing the effects of different extraction technologies on the absorbance of lycium pigment, with lycium as raw materials. The flash extraction and ultrasonic microwave synergistic extraction of Lycium barbarum pigment were studied by single factor experiment and response surface method. The results showed that the optimal technological conditions for flash extraction of lycium pigment were:material-to-liquid ratio (g/mL) 1 : 13, extraction voltage 113 V, extraction time 112 s, and the absorbance of lycium pigment under the conditions was 0.457. The optimal process conditions for ultrasonic-microwave synergistic extraction of lycium pigment are:material-to-liquid ratio (g/mL) 1 : 16, microwave power 613 W, extraction temperature 55 ℃, extraction time 32 min, and the absorbance of lycium pigment under the conditions is 0.502. Compared with the two extraction methods under the optimal conditions, the ultrasonic-microwave synergistic extraction method was better than the flash extraction method.