According to the packaging requirements of the product, the surface needs to be wrapped with film to ensure dust-proof, moisture-proof, cleaning and convenient transportation. The full-automatic on-line winding packaging machine control system is designed, which can be grafted in the current production line and replace the traditional manual operation mode, so as to improve the packaging efficiency, product beauty, reduce the labor intensity of workers and enterprise cost. According to the requirements and current situation of the current conventional product winding and packaging process, a full-automatic online winding and packaging machine control system based on PLC and touch screen is built. The control system is based on Siemens 1500 series PLC, equipped with digital / analog input and output modules, and combined with multi-sensor fusion technology. Through the Weinview MT6070ih touch screen on the packaging machine, the operation status of the whole packaging machine can be monitored and controlled.The control system not only can automatically transport the product to the turntable of the winding packaging machine and pack it according to the set requirements when receiving the packaging signal, but also can transfer the product to the next turnover area after the packaging is completed automatically. It can realize the maximum packaging speed of 40 bags/h under full-automatic mode.The practice shows that the full-automatic on-line winding packaging machine adopts the control system with PLC as the core, which is flexible in debugging, stable in operation, beautiful in product packaging effect, reduces the labor intensity of workers and the consumables of packaging materials, and improves the efficiency of product packaging and enterprise benefits.