A new type of polyurethane material was synthesized from 2,4 toluene diisocyanate (TDI), 2,2 dihydroxymethyl butyric acid (DMBA) and polycaprolactone (PCL). Different mass fractions of nano silver were added as antibacterial agent. The effects of R value (molar ratio of —NCO/—OH) and the amount of nano silver on the properties of the film were investigated. Polyurethane films were prepared from materials with different R values and nano-silver antibacterial agents. The effects of different R values and nanosilver dosage on the mechanical properties, oxygen permeability, hydrophilic/hydrophobic, water absorption, acid and alkali resistance and antibacterial properties of the films were analyzed. With the increase of R value, the mechanical properties of the film first increased and then decreased, the surface properties changed from hydrophilic to hydrophobic, the air permeability and water absorption decreased, and the resistance to alkali and acid increased. The addition of a small amount of nano silver has no significant effect on the mechanical properties, hydrophilic/hydrophobic properties, oxygen permeability and water absorption of the film, but increases the resistance to alkaline and decreases the resistance to acid. The higher the R value is, the better the properties of the film. The addition of nano silver gives the film some antibacterial properties.