In order to overcome the limitation that fabrication of oleophobic surfaces were always dependent on the use of fluorinated compounds, the amphiphobic wood surfaces were fabricated with non-fluorinated chemical which exhibited to resist against absorption of both water and oil. Methyltrimethoxysilane (MTMS) was mixed with 0.1 mol/L hydrochloric acid in a 4∶1 ratio, and then the mixture liquid was sonicated in an ice-bath for different lengths of time to induce hydrolysis. After hydrolysis, the wood was immersed in the hydrolyzed MTMS solutions to coated for 5 minutes. The elemental composition and surface chemistry of wood before and after coated with MTMS were analyzed by X-ray photoelectron spectroscopy (XPS) and fourier transformed infrared spectroscopy (FT-IR), the wetting behaviour for water and oil was measured with static contact angle, and the absorption of water and oil was measured by submerging the wood in the liquid for different times. The results showed that an abundance of Si element and the low surface energy of methyl groups were present on the coated wood surface; the water contact angles increased gradually from 79.8° to 90.7° as a function of hydrolysis time extending from 30 min to 240 min, while oil contact angles remained about at 50° essentially the same; the rate of water absorption before and after coated with MTMS was greater than that of oil absorption. The wood coated with MTMS was amphiphobicity and the hydrophobic stability raised with the increase of hydrolysis time, but the oleophobic stability was less affected by the hydrolysis time.