To establish an efficient and accurate analytical test method for quick detection of the type and content of volatile gases in cigarette packaging materials. With the help of gas chromatography-mass spectrometry (GC-MS), the detection performance of traditional headspace-gas chromatography-mass spectrometry (HS-GC-MS) and solid phase microextraction-gas chromatography-mass spectrometry (SPME-GC-MS) were compared respectively, and the parameters of SPME-GC-MS were optimized. The optimal analysis conditions for qualitative and quantitative analysis of the odor of cigarette materials by SPME-GC-MS were determined, and the packaging materials of cigarette packs with complicated printing processes were detected efficiently and accurately. The SPME-GC-MS method established in this paper can be used to qualitatively and quantitatively analyze the volatile odors of cigarette packaging materials and provides a new strategy for the quality evaluation of the packaging materials and the odor detection during the printing process.