Through exploring the use of antioxidant in food plastic packaging products, an analytical method of determining residues of eight antioxidants (N-Phenyl-2-naphthylamine, N-Phenyl-1-naphthylamine, Ethoxyquin, 1,4-Benzenediamine, N-Isopropyl-N'-phenyl-1,4-phenylenediamine, Dioctyldiphenylamine, 1,4-Dianilinobenzene, N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine) by HPLC-MS/MS was established. The samples were extracted by chloroform and methanol, then concentrated and redissolved by methanol. The extract was analyzed by HPLC-MS/MS and quantified by external standard method. The linear ranges of eight compounds ranging from 10.0 to 200.0 μg/L with correlation coefficients(R2) more than 0.999, and the detection lower limits were 5.0 μg/kg. The average recoveries of eight compounds were ranging from 81% to 116% at three spiked concentration levels of 10, 20 and 100 μg/kg with relative standard deviations not more than 3.77. The method is accurate, simple and efficient, and can be used for qualitative and quantitative determination of residues of eight antioxidants in food plastic packaging products.