A pallet loading optimization design system was developed to improve the efficiency and accuracy of pallet loading design. Firstly, the optimization algorithm was constructed for the four typical stacking forms of simple overlapping, positive and negative interleaving, crisscross, and rotary interleaving, with the surface utilization as the optimization objective. On this basis, a pallet loading optimization design system was designed. According to the optimization of the size data in the example, the area utilization ratio of overlapping and crisscross stacking, positive and negative interleaving stacking is 0.9, and the area utilization ratio of rotary interleaving stacking is 0.75. Therefore, from the comprehensive analysis of stacking efficiency and stacking stability, positive and negative interleaving stacking is the optimal stacking scheme.The system gives the optimal arrangement scheme according to four typical stacking modes, which is convenient for designers to consider the stacking efficiency and stability, and makes the stacking scheme more reasonable.