When polyacrylic ester resin agent is used in food packing, the safety of the residual acrylic acid ester monomer is concerned, this paper took n-butyl acrylate (nBA) as the research object, explored the headspace solid phase microextraction (HS-SPME) in different food simulation for the nBA enrichment effect, and on the basis of the optimization test, different condition of aluminum-plastic composite film was studied in the nBA to different food to simulate the effects of migration. The effects of different extraction heads, extraction time, extraction temperature and salt concentration on the extraction efficiency of nBA were compared and analyzed. Aluminum-plastic composite film was prepared from aluminum foil and polypropylene film (CPP) by water-based acrylate adhesive, and the migration law of nBA to acetic acid with a volume fraction of 4%, ethanol with a volume fraction of 10%, and olive oil simulants was studied in the short term thermal contact (70 ℃, 2 h), long-term storage (60 ℃, 10 d), UV treatment for 1 h before migration and under the condition of different temperature pasteurization and boiling (60, 80, 100, 121, 130 ℃). In all conditions, nBA migration in different simulants showed the law of 4% acetic acid >10% ethanol > olive oil. UV treatment had no significant influence on nBA migration (P > 0.05). At 80 ℃ and 100 ℃, the migration increased with the extension of boiling time, and the maximum migration at equilibrium was 32.7, 54.7 μg/kg respectively. At 121 ℃ and 130 ℃, the migration decreased with the extension of boiling time, and the maximum migration was 122.3, 115.2 μg/kg respectively. nBA was more likely to migrate in 4% acetic acid simulation. In different condition migration test studied in this paper, boiling had the greatest effects on nBA migration. The results of this study provide data support for the safety assessment of harmful substances in adhesive in the complex food supply chain.