To use Ansys to study the structural characteristics of a new type of double-layer honeycomb panel to optimize the structural parameters of the honeycomb panel and improve its compressive performance. Pressure test and model verification were performed on the honeycomb panel. The response surface results were used to analyze the cell height and thickness of the honeycomb element, as well as the relationship between the thickness of the middle panel and the stiffness of the honeycomb panel. Finally, the response surface optimization was used to optimize the honeycomb panel with multiple objectives. The stiffness of the honeycomb panel has a great relationship with the height of the honeycomb element, the wall thickness, and the thickness of the middle panel. The quality of the optimized honeycomb is reduced from 8.9979 g to 7.8215 g, a decrease of 13.07%, while the stiffness of the honeycomb panel is basically unchanged. Through the multi-objective optimization of Ansys Workbench, while ensuring the rigidity of the honeycomb plate, the quality of the honeycomb plate is effectively reduced, and the effectiveness of this type of solution is also proved.