The work aims to apply the biocompatible and recyclable polylactic acid wire in a fused deposition molding 3D printer to manufacture braille to make additive manufacturing of braille easier and cheaper, so as to solve the current problems of high cost and complicated operation in 3D printing for braille manufacturing. Firstly, braille text was designed by three-dimensional software, and the corresponding parameters were designed according to the characteristics and standards of braille text, such as dot diameter, dot pitch, square pitch, dot height, line spacing, etc. The designed 3D text was layered and printed with a single-screw extruded polylactic acid wire and a fused deposition 3D printer and different printing temperature, printing speed and layer height were set during printing. 4 parameters, such as smoothness, dimensional accuracy, wear resistance and water resistance, were used to evaluate the printing quality. The orthogonal test method was used to analyze the printing parameters layer height, printing temperature, and printing speed. When the printing temperature was 180 ℃, the printing speed was 90 mm/s, and the printing layer height was 0.1 mm, the quality of printed braille was excellent. The braille printed according to the optimal parameters is safe, non-toxic, durable, recyclable, degradable and resistant to friction and has a certain water resistance. Moreover, the technology has advantages of low cost and simple operation, which can be applied to some braille products.