The work aims to summarize the future development trend of drug packaging machinery industry by analyzing the current situation and characteristics of drug packaging machinery in foreign countries and China in view of the problems existing in Chinese drug packaging machinery industry. The performance parameters of the key core components of drug blister packaging machine, such as blister packaging machine, pillow packaging machine, origami machine, cartoning machine, etc., were analyzed. By comparing the advantages and disadvantages of domestic and foreign well-known drug packaging machinery, and considering the shortcomings and problems existing in Chinese drug packaging machinery industry, the current situation and development trend of drug blister packaging machine were analyzed deeply. By comparing the domestic and foreign medicine blister packaging machine, it was found that the new packaging machine needed to gradually realize the characteristics of flexibility, precision, integration and intelligence. The comparison and analysis of typical drug packaging machinery at home and abroad can provide a basis for the development of domestic drug packaging machinery and provide in-depth guidance and scientific design for new drug packaging machinery.