The work aims to study a transportation simulation test method by controlling the harmful factors of low air pressure and vibration at room temperature, to evaluate the protection performance of logistics package to products. Through the research and development of a low-pressure vibration test device, and combining it with the vibration system, the low-pressure environment conditions of plateau transportation or high-altitude transportation was simulated in the laboratory to realize a comprehensive simulation environment test method that can control the integrated environment factors of low-pressure and vibration at certain temperature and humidity. The low pressure vibration test system can meet the requirements of low pressure vibration test in ISTA 3A standard. A combined test method of low pressure and vibration was developed according to low pressure and random vibration test standards at home and abroad. It provides feasibility basis for the evaluation of the simulation test of high altitude truck transportation, railway transportation and air transportation.