In view of a series of problems in furniture industry and woodworking machinery processing enterprises, such as low mass production level of customized beam and column materials, low automation production level, high cost of producing single finished products, high labor intensity of workers, poor working environment, etc., the work aims to design a new type of CNC beam and column material six-sided machining production line control system. Delta DVP-48EH3 series programmable logic controller was used as the lower computer as the executive unit, the industrial control computer was used as the calculation unit of the upper computer, and the PLC expansion was used to connect series of supporting modules, to achieve human-computer interaction, analog acquisition, data exchange, motion control and other functions, and realize the high-speed and batch processing of beam and column materials through the coordinated action of various mechanical and electrical modules of the production line, so as to dock the subsequent packaging process and complete subsequent packaging and processing by virtue of the finished beam and column products. The control system of the production line had the function of automatic identification of wood blank contour and size, and completed the requirements of beam and column material six-sided milling, planing and mortise processing. The average processing efficiency of a product was 2.25 min, the failure rate of the control system was low, and the packaging rate of subsequent beam and column products was significantly improved. The virtual simulation processing test results show that the control system of the production line has excellent reliability and stability, meets the development trend of multi piece and small batch production mode based on customer customization in the furniture market, and completes the beam and column material order processing production requirements efficiently and quickly.