The work aims to propose a tape-free corrugated box which has self-locking function and can be used for many times in view of the usage of the tape seal and the short life cycle of express package. Firstly, the packaging material was determined. Secondly, an innovative structural design of the package was carried out to highlight the reliability of tape-free sealing and self-locking structure. In addition, the recycling process of the proposed box was clarified. Finally, the dynamics performance of the proposed box was analyzed by the verification tests and finite element simulations. The results of free drop test showed that the proposed box had good sealing strength after multiple uses. The drop simulation test results showed that the proposed box could reduce about 40% of the external impact load and had good cushioning performance. The maximum compressive strength of the proposed box was 3236 N, which was about 42% higher than that of the traditional slotted case. Besides, the production cost of the proposed box could decrease by about 60% compared with the traditional slotted case. The proposed box has the advantages of tape-free sealing, self-locking and anti-theft opening function, long life cycle, good protection performance, low production cost, etc.