The work aims to coat the box paperboard and corrugated paperboard with enzyme modified corn starch as the glue and study the effect of enzyme modified corn starch on the physical properties of paperboard. The medium-temperature amylase modified corn starch was used and its viscosity change was tested. Then, the enzyme modified corn starch was coated on the box paperboard and corrugated paperboard. Next, the bending resistance, ring compression strength, bursting resistance, folding endurance, tensile strength of the box paperboard were determined and the edgewise crush resistance and burst resistance of the corrugated paperboard were tested. After the corn starch with mass fraction of 10% was modified with 2.5 μL amylase and coated on the box paperboard, the physical properties of box paperboard were the best. Compared with the blank sample, the horizontal bending resistance increased by 380%, the vertical bending resistance increased by 464%, the ring compression strength increased by 53.2%, the vertical tensile strength increased by 10.6% and the horizontal tensile strength increased by 9.6%. The bursting resistance of the box paperboard did not change significantly, and the folding endurance decreased. After the corn starch with mass fraction of 10% was modified with 2 μL amylase and coated on the corrugated paperboard, the paperboard had the highest edgewise crush resistance. Compared with the blank sample, the edgewise crush resistance increased by 45.5%. The production process of enzyme modified corn starch is simple, and provides a reference for the preparation of high-performance paperboard.