The work aims to solve the low lycopene content in the water-based lycopene juice and increase the dissolution of lycopene. The prescription conditions were optimized by single factor and response surface experiments with the dissolution concentration of lycopene in juice as indicator. The optimum conditions of the co-solvent were as follows:the additive amount (mass fraction) of sucrose was 0.163%, the additive amount (mass fraction) of monoglyceride was 0.027%, and the additive amount (mass fraction) of hemp oil was 0.710%, the dissolution of lycopene in tomato juice was (27.90±0.03)μg/mL, compared with the juice without the co-solvent under the same process conditions, the dissolution of lycopene was more than twice. The compound co-solvent can effectively improve the dissolution of lycopene in tomato juice.